Modeling of ion permeation in calcium and sodium channel selectivity filters
نویسندگان
چکیده
منابع مشابه
Modeling of ion permeation in calcium and sodium channel selectivity filters.
Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups representative of the constituent amino acid side chains. Force-field minimizations were conducted to obt...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 2000
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(20000301)38:4<384::aid-prot4>3.0.co;2-m